Cryopreserved Primary Hepatocytes

ADME / DMPK / Toxicology / Pharmacology

From the Team Who Perfected Cryopreserved Hepatocytes

Discovery’s Gentest scientists continue to refine and develop hepatocyte products and services that optimize ADME and Toxicology Studies.

Discovery has raised the bar for the isolation, cryopreservation, and culturing of hepatocytes for use in the evaluation of drug metabolism, drug-drug interactions, and drug toxicity. Discovery’s Dr. Albert Li has continually refined the proprietary cryopreservation technology and collection processes that now yield the industry’s highest performing hepatocytes, 999Elite™ Human Hepatocytes. Discovery now offers the largest hepatocyte inventory in the industry.

Use Discovery’s High Quality Cryopreserved Hepatocytes To:

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Avoid inaccurate assessment of human drug properties

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Choose your in vivo species wisely 

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Understand drug metabolism and toxicity

Product Details:

999Elite™ Human Hepatocytes

The highest quality human hepatocytes available:

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>90% Viability

The highest percentage of viable cells recovered per vial for optimal study conditions

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>90% Confluency

Pre-screened for plateability, metabolic activity, CYP induction, and transporter efflux activity

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>9 days of culture duration

The greatest longevity in culture compared to the other standards

Individual and Pooled Donor Lots Available

Plateable, Inducible Grade Hepatocytes

Analyzed and confirmed for successful plateability and inducibility

Individual and Pooled Lots Available

Species Available: 

  • Human
  • Non-Human Primate
  • Dog
  • Rat
  • Mouse

Suspension Grade Hepatocytes

Analyzed and confirmed for utility in cell suspensions

Individual and Pooled Lots Available

Species Available: 

  • Human
  • Non-Human Primate
  • Dog
  • Rat
  • Mouse

MetMax Hepatocytes
 

Permeabilized, co-factor supplemented hepatocytes for metabolism studies

Individual and Pooled Lots Available

Species Available: 

  • Human
 

Pair Discovery Hepatocytes with our optimized Hepatocyte media

with over 30 years of hepatocyte culture experience, our team has optimized a selection of media recipes to help customers obtain reliable results.

OnDemand Hepatocytes

Optimally plating hepatocytes requires hours of preparation and can be quite challenging. Discovery’s OnDemand™ pre-plated hepatocytes give you all of the advantages of our high-quality cryopreserved products with none of the hassle. Our proprietary shipping media allows up to 2 days in transit without sacrificing quality. Just submit your request and timeline and our seasoned hepatocyte scientists will thaw, plate, and ship these products to your lab.

Schedule your lab work without the fear of poor attachment rates and other challenges that can arise during thawing and plating procedures.

Product
Features

  • No hassle, no frustration; save your valuable time for other tasks
  • High-quality cells guaranteed with Discovery’s scientists’ expertise in hepatocytes
  • Convenient, ready-to-go
  • Fast delivery, expect your plates as quick as within 1-2 business days
  • Large selection; available in human, mouse, rat, dog, non-human primate, etc.

Our Cryopreservation Technology Is the Secret to Achieving the Highest Quality Cryopreserved Hepatocytes

  • The highest quality (viability & plate-ability)
  • The highest volume of vials produced per donor for optimal study repeatability
  • The greatest longevity in culture compared to the competition

Technology

Our Cryopreservation Technology Is the Secret to Achieving the Highest Quality Cryopreserved Hepatocytes

  • The highest quality (viability & plate-ability)
  • The highest volume of vials produced per donor for optimal study repeatability
  • The greatest longevity in culture compared to the competition

Characterizations

Our donor characterization includes:

  • Gender
  • Age
  • Race
  • Cause of Death
  • BMI
  • Smoking
  • Alcohol
  • Substance abuse
  • Medical history
  • Infectious Disease: CMV, HIV, HBV, HCV

Each lot of hepatocytes is carefully assessed and characterized for:

  • Grade
  • Plateability
  • Viability
  • Confluency
  • Culture Duration
  • P450 Inducibility
  • Transporter activity
  • Post thaw viability and yield

To propel your projects with The Power of Discovery.™

Contact Us Today

Let us know about your project!

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